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The antibacterial effect and the incidence of post-operative pain after the application of nano-based intracanal medications during endodontic retreatment: a randomized controlled clinical trial

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dc.contributor.authorFahim, Mahmoud M.
dc.contributor.authorSaber, Shehab Eldin Mohamed
dc.contributor.authorNagy , Mohamed Mokhtar
dc.contributor.authorSchafer, Edgar
dc.contributor.authorElkhatib, Walid F.
dc.date.accessioned2022-09-19T11:39:04Z
dc.date.available2022-09-19T11:39:04Z
dc.date.issued2022-02-01
dc.description.abstractObjective: This clinical trial aimed to evaluate the effect of nano-silver and nano-calcium hydroxide intracanal medicaments (ICM) during retreatment regarding their antibacterial effect and their effect on post-operative pain and flare-ups. Materials and methods: Sixty-nine patients scheduled for endodontic retreatment were included in this randomized clinical trial and randomly allocated to 3 equal groups (n = 23) according to the type of ICM used. The first microbial sampling (S1) representing the original microbiota was obtained after the removal of the old canal filling. After chemo-mechanical debridement, another sample (S2) was obtained representing the microbial state before ICM application. Patients were randomly allocated to receive either nano-silver (nano-Ag), nano-calcium hydroxide (nano-CH), or calcium hydroxide (CH) as ICM. Patients rated their pain pre-operatively and then after 6, 12, 24, 48, and 72 h. During the second visit (7 days later), the last microbial sample (S3) was obtained after removal of the ICM. Reduction of total bacterial and total E. faecalis counts and the biofilm-forming capability of the existing microbiota were determined. Results: Results showed reduction in total bacterial count, total E. faecalis count and the biofilm-forming,capability of the existing microbiota after chemo-mechanical debridement (S1-S2) and after the application of ICM (S3-S2). However, the reduction after cleaning and shaping was significantly more pronounced (p < 0.001) compared to the effect of ICM application, with no difference between the 3 ICM (p > 0.05). Post-operative pain was significantly reduced at the 48- and 72-h intervals after the application of nano-Ag and nano-CH only (p < 0.001), with no significant difference between these two ICM (p > 0.05). The incidence of flare-ups in all groups was similar (p > 0.05). Conclusions: The antibacterial effect of the nano-Ag and nano-CH was equivalent to that of CH, but they contributed to better pain control.
dc.identifier10.1007/s00784-021-04196-w
dc.identifier.citationFahim, M., Saber, S.E.M., Elkhatib, W. et al. The antibacterial effect and the incidence of post-operative pain after the application of nano-based intracanal medications during endodontic retreatment: a randomized controlled clinical trial. Clin Oral Invest 26, 2155–2163 (2022). https://doi.org/10.1007/s00784-021-04196-w
dc.identifier.issn14326981
dc.identifier.other2-s2.0-85117856495
dc.identifier.pagesPages 2155–2163
dc.identifier.urihttps://research.gu.edu.eg/handle/123456789/109
dc.language.isoen
dc.publisherSpringer Nature
dc.relation.ispartofClinical Oral Investigations
dc.relation.ispartofseriesClinical Oral Investigations
dc.rightsfalse
dc.source.urihttps://link.springer.com/article/10.1007/s00784-021-04196-w
dc.subjectBacterial reduction
dc.subjectCalcium hydroxide
dc.subjectEndodontic retreatment
dc.subjectFlare-ups
dc.subjectPost-operative pain
dc.subjectNano-silver
dc.subjectNano-calcium hydroxide
dc.subjectIntracanal medications
dc.titleThe antibacterial effect and the incidence of post-operative pain after the application of nano-based intracanal medications during endodontic retreatment: a randomized controlled clinical trial
dc.typeArticle
dspace.entity.typePublication
oaire.citation.issue2
oaire.citation.volume26
relation.isAuthorOfPublication92797dd3-4a77-4ef2-b20d-bc2e3a26d692
relation.isAuthorOfPublication.latestForDiscovery92797dd3-4a77-4ef2-b20d-bc2e3a26d692
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