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Antibiofilm activity of green synthesized silver nanoparticles against biofilm associated enterococcal urinary pathogens

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dc.contributor.authorSwidan, Nada S.
dc.contributor.authorHashem, Yomna A.
dc.contributor.authorYassien, Mahmoud A.
dc.contributor.authorElkhatib, Walid F.
dc.date.accessioned2022-09-20T11:17:03Z
dc.date.available2022-09-20T11:17:03Z
dc.date.issued2022-03-09
dc.description.abstractAbstract: Biofilm-formed enterococcal urinary tract clinical isolates (n = 92) were used for studying the antibiofilm activity of cinnamon, ginger, and chemical AgNPs. The average particle sizes of cinnamon, ginger, and chemical AgNPs were 8.7, 41.98, and 55.7 nm, respectively. The results of Fourier transform infrared analysis revealed that phytocompounds, such as cinnamaldehyde and gingerol, were the main compounds incorporated in the synthesis of cinnamon and ginger AgNPs, respectively. The purity and crystalline nature of the AgNPs have been confirmed by energy dispersive X-ray and X-ray Diffraction analysis. The results of antimicrobial activity showed that MIC of ginger, cinnamon, and chemical AgNPs were 37.64, 725.7, and 61.08 Î¼g/ml, respectively. On studying the antibiofilm activity of AgNPs at sub-MIC values (1/2, 1/4, and 1/8 MIC), the results revealed that it was concentration dependent. Therefore, further studies were carried out to evaluate the antibiofilm activity of AgNPs at a concentration of 18 Î¼g/ml. The results showed that ginger and chemical AgNPs reduced the formed biofilm to 39.14% and 65.32% and the number of adherent cells on the urinary catheter surface to 42.73% and 69.84%, respectively, as compared to that of the control, while cinnamon AgNPs showed no significant activity. Accordingly, ginger AgNPs had the most potent antibacterial and antiadherent activity against biofilm-associated enterococcal isolates.
dc.identifier.citationSwidan, N.S., Hashem, Y.A., Elkhatib, W.F. et al. Antibiofilm activity of green synthesized silver nanoparticles against biofilm associated enterococcal urinary pathogens. Sci Rep 12, 3869 (2022). https://doi.org/10.1038/s41598-022-07831-y
dc.identifier.doi10.1038/s41598-022-07831-y
dc.identifier.issn2045-2322
dc.identifier.pages13 Pages
dc.identifier.urihttps://research.gu.edu.eg/handle/123456789/113
dc.language.isoen
dc.publisherSpringer Nature
dc.relation.ispartofScientific Reports
dc.source.urihttps://www.nature.com/articles/s41598-022-07831-y
dc.subjectDiseases
dc.subjectMicrobiology
dc.subjectNanoscience and technology
dc.titleAntibiofilm activity of green synthesized silver nanoparticles against biofilm associated enterococcal urinary pathogens
dc.typeArticle
dspace.entity.typePublication
oaire.citation.issue1
oaire.citation.volume12
relation.isAuthorOfPublication92797dd3-4a77-4ef2-b20d-bc2e3a26d692
relation.isAuthorOfPublication.latestForDiscovery92797dd3-4a77-4ef2-b20d-bc2e3a26d692
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