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Biogenic and biocompatible silver nanoparticles for an apoptotic anti-ovarian activity and as polydopamine-functionalized antibiotic carrier for an augmented antibiofilm activity.

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dc.contributor.authorAboelmaati, Mohamed G.
dc.contributor.authorAbdel Gaber, Sara A.
dc.contributor.authorSoliman, Wafaa E.
dc.contributor.authorAbdelhameed, Amr M.
dc.contributor.authorSahyon, Heba A.
dc.contributor.authorEl-Kemary, Maged
dc.contributor.authorElkhatib, Walid F.
dc.date.accessioned2022-09-15T11:34:40Z
dc.date.available2022-09-15T11:34:40Z
dc.date.issued2021-10-01
dc.description.abstractSilver nanoparticles (AgNPs) could be employed in the combat against COVID-19, yet are associated with toxicities. In this study, biogenic and biocompatible AgNPs using the agro-waste, non-edible Hibiscus sabdariffa stem were synthesized. Under optimized reaction conditions, synthesized green AgNPs were crystalline, face cubic centered, spherical with a diameter of around 17 nm and a surface charge of -20 mV. Their murine lethal dose 50 (LD50) was 4 folds higher than the chemical AgNPs. Furthermore, they were more murine hepato- and nephro-tolerated than chemical counterparts due to activation of Nrf-2 and HO-1 pathway. They exerted an apoptotic anti-ovarian cancer activity with IC50 value 6 times more than the normal cell line. Being functionalized with polydopamine and conjugated to either moxifloxacin or gatifloxacin, the conjugates exerted an augmented antibiofilm activity against Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii biofilms that was significantly higher than antibiotic alone or functionalized AgNPs suggesting a synergistic activity. In conclusion, this study introduced a facile one-pot synthesis of biogenic and biocompatible AgNPs with preferential anti-cancer activity and could be utilized as antibiotic delivery system for a successful eradication of Gram-negative biofilms.
dc.identifier.citationAboelmaati, M. G., Abdel Gaber, S. A., Soliman, W. E., Elkhatib, W. F., Abdelhameed, A. M., Sahyon, H. A., & El-Kemary, M. (2021, October). Biogenic and biocompatible silver nanoparticles for an apoptotic anti-ovarian activity and as polydopamine-functionalized antibiotic carrier for an augmented antibiofilm activity. Colloids and Surfaces B: Biointerfaces, 206, 111935. https://doi.org/10.1016/j.colsurfb.2021.111935
dc.identifier.other34252691
dc.identifier.pages13 Pages
dc.identifier.urihttps://research.gu.edu.eg/handle/123456789/107
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofColloids and Surfaces B: Biointerfaces
dc.source.urihttps://www.sciencedirect.com/science/article/abs/pii/S0927776521003799?via%3Dihub
dc.subjectAntibiotic delivery system
dc.subjectAnticancer activity
dc.subjectBiocompatibility
dc.subjectBiogenic silver nanoparticles (AgNPs)
dc.subjectGram negative biofilms
dc.subjectPolydopamine functionalization
dc.titleBiogenic and biocompatible silver nanoparticles for an apoptotic anti-ovarian activity and as polydopamine-functionalized antibiotic carrier for an augmented antibiofilm activity.
dc.typeArticle
dspace.entity.typePublication
oaire.citation.volume206
relation.isAuthorOfPublication92797dd3-4a77-4ef2-b20d-bc2e3a26d692
relation.isAuthorOfPublication.latestForDiscovery92797dd3-4a77-4ef2-b20d-bc2e3a26d692
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