Publication: Nanobiotic formulations as promising advances for combating MRSA resistance: susceptibilities and post-antibiotic effects of clindamycin, doxycycline, and linezolid
Nanobiotic formulations as promising advances for combating MRSA resistance: susceptibilities and post-antibiotic effects of clindamycin, doxycycline, and linezolid
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Date
2021-12-13
Type
Article
Authors
Mohamed, Mennatallah A.
Nasr, Maha
Eltayeb, Wafaa N.
Elshamy, Aliaa A.
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Publisher
Royal Society of Chemistry
Publisher DOI
10.1039/d1ra08639a
Source
https://pubs.rsc.org/en/content/articlelanding/2021/ra/d1ra08639a
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Abstract
Antimicrobial activity and post-antibiotic effects (PAEs) are both important parameters in determination of the dosage regimen of antimicrobial agents. In the present study, antimicrobial activity and PAEs of clindamycin, doxycycline, linezolid, and their nanobiotic formulations were evaluated against two methicillin resistant Staphylococcus aureus clinical isolates (MRSA) encoded (MRSA-S1 and MRSA-S2). Nanobiotic formulations increased the susceptibility of MRSA isolates by 4–64 folds as compared to their conventional ones. The PAE values were determined after exposure of MRSA isolates for 1 h to 10× the MICs of the tested antibiotics. The duration of PAEs were recorded after bacterial growth in Mueller Hinton broth (MHB) free from antibiotic has been restored. The PAE values for MRSA-S1 were 2.5 h for the conventional antibiotics. However, the PAEs for nanobiotics were 4 h for both clindamycin and linezolid, while 3 h for doxycycline. For MRSA-S2, linezolid and linezolid nanobiotics PAEs were 3 h. PAEs of clindamycin and clindamycin nanobiotics were 3.75 h and 4 h, respectively. Doxycycline and doxycycline nanobiotics revealed the same PAEs patterns of 3.5 h. The findings of the current study may positively influence the pharmacodynamics of the antibiotics and consequently the dosage regimen of nanobiotics as well as on their clinical outcome.
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Keywords
Bacterial, MRSA-S1, MICs, Post-antibiotic
Citation
Mohamed, M. A., Nasr, M., Elkhatib, W. F., Eltayeb, W. N., Elshamy, A. A., & El-Sayyad, G. S. (2021). Nanobiotic formulations as promising advances for combating MRSA resistance: susceptibilities and post-antibiotic effects of clindamycin, doxycycline, and linezolid. RSC Advances, 11(63), 39696–39706. https://doi.org/10.1039/d1ra08639a
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RSC Advances
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Volume
11
Issue
63
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© 2023 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.