Publication:
GC-MS/MS Quantification of EGFR Inhibitors, β-Sitosterol, Betulinic Acid, (+) Eriodictyol, (+) Epipinoresinol, and Secoisolariciresinol, in Crude Extract and Ethyl Acetate Fraction of Thonningia sanguinea

Simple item page
dc.contributor.authorAbdelhameed, Reda F. A.
dc.contributor.authorAlkhalidi, Hala M.
dc.contributor.authorElhady, Sameh S.
dc.contributor.authorFadil, Sana A.
dc.contributor.authorRefaey, Mohamed S.
dc.contributor.authorAbouelela, Mohamed E.
dc.contributor.authorEl-Shoura, , Ehab A. M.
dc.date.accessioned2023-01-15T09:53:29Z
dc.date.available2023-01-15T09:53:29Z
dc.date.issued2022-03-19
dc.description.abstractThe genus Cotula (Asteraceae) comprises about 80 species, amongst them Cotula anthemoides L. It is a wild plant growing in Egypt that possesses many traditional uses as a headache, colic, and chest cold remedy. In our study, the chemical composition of C. anthemoides essential oils was analyzed using GC-MS spectroscopy. Sixteen components of leave and stem oils and thirteen components of flower oils were characterized. The main components in both essential oil parts were camphor (88.79% and 86.45%) and trans-thujone (5.14% and 10.40%) in the leaves and stems and the flowers, respectively. The anti-inflammatory activity of the oils in lipopolysaccharide-stimulated RAW 264.7 macrophage cells was evaluated. The flower oil showed its predominant effect in the amelioration of proinflammatory cytokines and tumor necrosis factor-α, as well as cyclooxygenase-2. The bornyl acetate showed the highest affinity for the cyclooxygenase-2 receptor, while compound cis-p-menth-2-ene-1-ol had the best affinity for the tumor necrosis factor receptor, according to the results of molecular docking. In addition, the molecule cis-β-farnesene showed promising dual affinity for both studied receptors. Our findings show that essential oils from C. anthemoides have anti-inflammatory properties through their control over the generation of inflammatory mediators. These findings suggest that C. anthemoides essential oils could lead to the discovery of novel sources of anti-inflammatory treatments.
dc.identifier.citationRefaey, M., Abouelela, M., El-Shoura, E., Alkhalidi, H., Fadil, S., Elhady, S., & Abdelhameed, R. (2022). In Vitro Anti-Inflammatory Activity of Cotula anthemoides Essential Oil and In Silico Molecular Docking of Its Bioactives. Molecules, 27(6), 1994. https://doi.org/10.3390/molecules27061994
dc.identifier.doi10.3390/molecules27061994
dc.identifier.pages13
dc.identifier.urihttp://10.4.205.66:4000/handle/123456789/177
dc.journaltitle.linkMolecules
dc.language.isoen
dc.publisherMDPI
dc.source.urihttps://www.mdpi.com/1420-3049/27/6/1994
dc.subjectmolecular modeling
dc.subjectcyclooxygenase
dc.subjectphytoconstituents
dc.subjecttumor necrosis factor
dc.subjectAsteraceae
dc.titleGC-MS/MS Quantification of EGFR Inhibitors, β-Sitosterol, Betulinic Acid, (+) Eriodictyol, (+) Epipinoresinol, and Secoisolariciresinol, in Crude Extract and Ethyl Acetate Fraction of Thonningia sanguinea
dc.typeArticle
dspace.entity.typePublication
oaire.citation.issue6
oaire.citation.volume27
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
molecules-27-01994-with-cover.pdf
Size:
1.14 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed to upon submission
Description:
Download
Collections
Articles