Publication: Clinical characteristics of Egyptian male patients with COVID‐19 acute respiratory distress syndrome
Clinical characteristics of Egyptian male patients with COVID‐19 acute respiratory distress syndrome
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Publisher DOI
10.1371/journal.pone.0249346
Date
2021-04-16
Type
Article
Authors
Doghish, Ahmed S.
Elkhatib, Walid F.
Hassan, Essam A.
Elkhateeb, Ahmed F.
Mahmoud, Eman E.
Ahmed, Mona I.
Khalil, Mahmoud A. F.
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Plos
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https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0249346
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Abstract
Background: Coronavirus disease 2019 (COVID-19) is a serious <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="https://en.wikipedia.org/wiki/Infectious_disease" xlink:type="simple">illness</jats:ext-link> caused by <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2" xlink:type="simple">severe acute respiratory syndrome coronavirus 2</jats:ext-link> (SARS-CoV-2) and in severe cases associated with acute respiratory distress syndrome (ARDS).
Objective: To describe the clinical characteristics of patients with ARDS-COVID-19.
Materials and methods: <jats:p>This study involved 197 male Egyptian participants, among them111 COVID-19 patients presented with ARDS, 60 COVID-19 patients presented with non-ARDS, and 26 Non-COVID-19 patients. We reported the analysis results of clinical and laboratory information, including blood routine tests, blood biochemistry parameters [aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine and C‐reactive protein (CRP)], thrombotic activity (D‐dimer) and serum ferritin and lactate dehydrogenase (LDH).
Results: The levels of hemoglobin, AST, creatinine, monocyte count, monocyte %, RBC count, TLC, and platelet count were not significantly different among the groups. The lymphopenia and increased CRP, ALT, D-dimer, ferritin, and LDH were observed in patients with ARDS-COVID-19.
Conclusion: COVID-19 patients with ARDS presented with lymphopenia, increased thrombotic activity, increased CRP, LDH, and ferritin levels. The results revealed that CRP, D-dimer, LDH levels, and lymphopenia have a significant association with the COVID-19 severity and can be used as biomarkers to predict the disease severity.
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Keywords
COVID 19, Ferritin, Acute respiratory distress syndrome, Lymphocytes, Monocytes, Lymphopenia, Clinical laboratories, Thin-layer chromatography
Citation
Doghish AS, Elkhatib WF, Hassan EA, Elkhateeb AF, Mahmoud EE, Ahmed MI, et al. (2021) Clinical characteristics of Egyptian male patients with COVID‐19 acute respiratory distress syndrome. PLoS ONE 16(4): e0249346. https://doi.org/10.1371/journal.pone.0249346
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PLOS ONE
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16
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4
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© 2023 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.