School of Applied Health Sciences Technology
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The field of Applied Health Sciences Technology is a brand new field in Egypt. It was designed to respond to the market need for health technology professionals.
At GU, we provide our students with all the knowledge, skills, and practical experience to deal with modern-day challenges using critical thinking and advanced tools.
At GU, we provide our students with all the knowledge, skills, and practical experience to deal with modern-day challenges using critical thinking and advanced tools.
This field offers 4 completely new programs; Medical Laboratory, Prosthetic Dentistry, Prosthetic & Orthotic Devices and Radiology & Medical Imaging. All the programs are delivered through an innovative teaching method, with the support of 11 of the most advanced labs and workshops in the MENA region.
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- PublicationOpen AccessErythroferrone Expression in Anemic Rheumatoid Arthritis Patients: Is It Disordered Iron Trafficking or Disease Activity?(Dove Press Ltd, 2021-09-07) Youssef, Soha R.; Hassan, Esraa H.; Morad, Caroline S.; El-Gamal, Rasha A.; Elged, Adel A. ElazabErythroferrone (ERFE) is well acknowledged for its inhibitory function on hepcidin synthesis in the liver during stress erythropoiesis, thereby ensuring sufficient iron supply to bone marrow erythroblasts. Hepcidin plays an indispensable role in the pathogenesis of anemia of chronic disease (ACD). Thus, ERFE was suggested to protect against ACD in various diseases. Rheumatoid arthritis (RA) is commonly involved with ACD and high hepcidin levels, with a further increase of the latter in active states. The present study is a case-control study that aimed to determine the pattern of ERFE expression in RA patients with concomitant ACD and study its relationship with hepcidin, erythropoietin (EPO) and disease activity.
- PublicationOpen AccessErythroferrone Expression in Anemic Rheumatoid Arthritis Patients: Is It Disordered Iron Trafficking or Disease Activity?(Dove Press, 2021-09-07) Youssef, S. R.; Hassan, Esraa H.; Morad, Caroline S.; Elged, Adel A. Elazab; El-Gamal, Rasha A.
Purpose
Erythroferrone (ERFE) is well acknowledged for its inhibitory function on hepcidin synthesis in the liver during stress erythropoiesis, thereby ensuring sufficient iron supply to bone marrow erythroblasts. Hepcidin plays an indispensable role in the pathogenesis of anemia of chronic disease (ACD). Thus, ERFE was suggested to protect against ACD in various diseases. Rheumatoid arthritis (RA) is commonly involved with ACD and high hepcidin levels, with a further increase of the latter in active states. The present study is a case-control study that aimed to determine the pattern of ERFE expression in RA patients with concomitant ACD and study its relationship with hepcidin, erythropoietin (EPO) and disease activity.Patients and methods
Fifty-five RA patients with ACD were categorized into active and inactive RA using the disease activity score (DAS28); 15 healthy subjects were included as control subjects. ERFE was measured for patients and control subjects using quantitative real-time polymerase chain reaction, in addition to testing for CBC, ESR, CRP, iron profile parameters and hepcidin. EPO was assessed for patients of both active and inactive RA groups.Results
ERFE and hepcidin showed the highest levels in active RA; ERFE values were similar in control subjects and inactive RA patients, while hepcidin was significantly higher in inactive RA than control subjects. Patients with high ERFE levels had higher RBC, Hct, MCV, hepcidin and EPO levels. Stepwise regression analysis has identified DAS28 and disease duration as the best predictors of ERFE values, whereas ERFE and hepcidin were independent predictors of disease activity.Conclusion
We introduce ERFE as a novel marker of RA activity. Although the inhibitory effect of ERFE on hepcidin is not evident, our results still indicate that ERFE may have a beneficial erythropoietic effect in the context of ACD in RA disease activity. - PublicationOpen AccessFeasibility study in assessment of congenital cardiovascular malformation by recent technique of fetal cardiac MR imaging(Springer Nature, 2022-12-01) Habeeb, Nevin M. M.; Ibrahim, Ahmed Samir; Megahed, Shimaa Rashad; Yassin, Aya; Hassan, Hend Galal Eldeen Mohamed AliBackground: Abnormalities of the cardiovascular system are the most common congenital diseases in the fetus and the first cause of infant mortality. Echocardiography is still the method of choice to visualize the fetal cardiac cardiovascular abnormalities, yet cardiovascular magnetic resonance (CMR) is relatively unaffected by maternal and fetal conditions such as maternal obesity, uterine myoma, twins, oligohydramnios, fetal position and rib calcification, which particularly impair sonographic visualization of the fetal heart. Fetal cardiac MR imaging is a novel MRI technique which can provide valuable information that could add to the prenatal diagnosis and evaluation of cardiac and most of extra-cardiac anomalies. In this work, we aimed to highlight the advantage of FCMRI over fetal echocardiography in assessment of fetal congenital cardiac anomalies. Results: Fifty-Two fetuses with suspected or diagnosed congenital cardiac anomalies. All cases underwent detailed history taking, underwent fetal echocardiography using suitable curvilinear probe and performed according to standard protocol, then fetal cardiac MR was done with Balanced fast field echo, Black blood single shot, white blood Cine, Real-time 3D dynamic sequences, images were acquired in the transverse, four-chamber, short-axis, coronal and oblique sagittal views. Findings of fetal echocardiography were compared with that of cardiac MRI and with standard post-natal echocardiography. Prenatal Echo and fetal cardiac MRI showed significant moderate agreement between the two modalities in the detection of different congenital cardiac anomalies, Kappa test: 0.500; p value 0.021. Fetal MRI had a significant role in detection of extra cardiac anomalies in most cases. Comparing to gold standard post-natal echo. Accuracy of fetal CMRI is 95.5% and of fetal Echo is 86.4% regarding overall cardiac anomalies: Conclusion: Fetal cardiac MR imaging as an adjunct to fetal echocardiography may provide valuable information that could add to the prenatal diagnosis and evaluation of cardiac and most of extra cardiac anomalies.
- PublicationOpen AccessInterventricular Septal Thickness and Doppler Indices as Multiparametric Assessment of High-Risk Pregnancy and Their Relation to Fetal Outcome(2022-04-01) Abd El Wahed, Mona Aly; Abdel Aziz , Mohamed M.; Hassan, Hend Galal Eldeen Mohamed AliBackground: Basic ultrasound measurement is not enough for proper assessment for the high-risk pregnancy like gestational diabetes mellitus and preeclampsia. Objective: This study aimed to add more parameters for evaluation of high-risk pregnancy including Doppler parameter and interventricular septal thickness, and their reflection on fetal outcome Patients and methods: 75 pregnant women were presented between 28-38 weeks gestation. They were divided into three groups: Group I included 25 pregnant diabetic women, group II included 25 pregnant women with gestational diabetes mellitus (GDM) and preeclampsia, and group III included 25 normal pregnant women as a control group (NC). Fetal hemodynamic indices were measured to all included groups and represented as the resistance index (RI), pulsatility index (PI) of umbilical artery (UA), middle cerebral artery (MCA), and interventricular septal (IVS) thickness. Results: The independent samples t-test showed that fetal weight, as well as the abdominal circumference (AC), was larger in GDM than in NC (P < 0.05) while were smaller in GDM with preeclampsia than in NC. Also, IVS thickness was larger in GDM than in NC (P < 0.05), while t-test showed that umbilical PI was higher in preeclampsia than in NC (P < 0.05) vice versa the MCA PI was lower in the preeclampsia than in NC (P < 0.05). Conclusion: Doppler indices especially MCA and umbilical PI as well as the interventricular septal thickness in late pregnancy were helpful in the diagnosis and assessment of high-risk pregnancy as well as their follow-up and in turn they could be considered as an indicator of poor fetal outcome.
- PublicationOpen AccessRole of MRI in diagnosis of prostate cancer and correlation of results with transrectal ultrasound guided biopsy “TRUS”(Springer Nature, 2022-12-01) Ahmed, Islam Hussien Abd Elaziz; Abo ElMaaty, Mohamed El Gharib; El Metwally, Shaima El Metwally ElDaisty; Hassan, Hend Galal Eldeen Mohamed AliBackground: Prostate cancer is the most common cancer in elderly men, and the second leading cause of cancer-related death in developed countries. For a long time, TRUS is used in screening, diagnosis of prostate lesions. Recently the implementation of multi parametric MRI into a screening program currently seems to be the most promising technique to improve the early detection of prostate cancer. Results: Thirty Patients were referred from urological outpatient clinics complaining of urological symptoms (dysuria, frequency and urine retention). The study was carried, and the patients were submitted to Ultrasonography, conventional magnetic resonance, diffusion weighted images and MR spectroscopy techniques, these results were correlated with histopathological data. In this study Conventional MRI has moderate sensitivity 81.8% and low specificity 37.3% in diagnosing prostate malignancy. Using of mpMRI combination of diffusion-weighted, Dynamic contrast enhanced and MR spectroscopic imaging is a promising approach for discriminating between benign and malignant lesions in the PZ and increase sensitivity 100% and specificity 96.6% in diagnosing prostate malignancy. Conclusions: The standard for the definitive diagnosis of prostate cancer is trans-rectal ultrasound biopsy. However, TRUS guided biopsy has a significant sampling error and can miss up to 30% of cancers and may show underestimation of Gleason grade, especially in anteriorly located tumors. It may lead to an increase in complications. MRI has an essential role to play in making safer in diagnosis. It can aid in staging also and surgery or radiation treatment planning. Although T2W MRI has been used widely for diagnosis on the basis of its excellent soft tissue resolution, but its accuracy for the detection and localization of cancer prostate is unsatisfactory. The implementation of multi parametric MRI: MR spectroscopy, Dynamic contrast enhanced and diffusion weighted imaging into a diagnosis program improve the diagnostic performance. These advances are beginning to translate into better treatment selection and more accurate image-guided therapies. In addition, early detection of local recurrence.
- PublicationOpen AccessRole of prenatal fetal echocardiography in the assessment of intrauterine growth restriction(Springer Nature, 2022-12-01) Ali, Nesma Saied Ahmed Ahmed; Ibrahim, Fatma Salah Eldeen Mohammed; Shalaby, Nevine AbdelMonem Tawfik; Hassan, Hend Galal Eldeen Mohamed AliBackground: Intrauterine growth restriction (IUGR) is a common diagnosis in obstetrics and carries an increased risk of perinatal mortality and morbidity. Identification of IUGR is crucial because proper evaluation and management can result in a favourable outcome. Cardiovascular dysfunction and remodelling is a central feature of IUGR. The aim of the study was to use the left modified myocardial performance index (MPI), assess cardiac function in foetuses with intrauterine growth restriction (IUGR) compared to healthy foetuses, and to connect the relationship between changes in MPI and perinatal outcome. A prospective study was conducted with 60 singleton foetuses between 24 and 40 weeks of gestation without foetal chromosomal abnormalities or major malformations, divided into two groups: 30 women with intrauterine growth restriction (30 women) and another 30 women with normal pregnancies (foetal growth pattern appropriate for gestational age and normal heart findings with normal sinus rhythm) who were matched for gestational age and served as the controls. Trans-abdominal ultrasound examination was done with 3.5–7-MHz curvilinear Probe (GE Medical US equipment). The umbilical arteries, middle cerebral artery, and ductus venosus all had blood flow velocity waveforms recorded. The pulsatility index (PI), cerebroplacental ratio (CPR), and Doppler velocimetry (DV) of the umbilical artery were all measured. All foetuses had their myocardial performance index assessed. Normal and abnormal umbilical artery(UA) Doppler, as well as normal and abnormal MCA Doppler, were used to examine the intrauterine growth restriction group. Foetal growth restrictions (FGR) foetuses' Mod-MPI values were compared to gestation-matched controls. The outcomes of the perinatal period were documented. Results: Intrauterine growth restriction foetuses with defective umbilical arteries Doppler had a substantially higher mean left myocardial performance index (mean 0.58 SD 0.093) than healthy foetuses (mean 0.45SD 0.070) (P 0.001). When compared to the control group, IUGR foetuses with abnormal left myocardial performance index had a significantly worse perinatal outcome and higher morbidity. When compared to intrauterine growth restriction foetuses with normal MPI, intrauterine growth restriction foetuses with defective left MPI had a significantly worse perinatal outcome (whether the UA Doppler was normal or abnormal). Based on the perinatal result, the foetal myocardial performance index was linked to the severity of foetal impairment in intrauterine growth restriction foetuses. Conclusion: MPI has the potential to be a useful technique for evaluating IUGR pregnancies and predicting neonatal outcome. Within the IUGR foetuses, MPI foetal echocardiographic characteristics can define a high-risk group.