Person:
Elkhatib, Walid F.

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0000-0001-5815-3200
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56593725900
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Walid F. Elkhatib
Last Name
Elkhatib
First Name
Walid F.
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Galala University
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Professor Head of Microbiology Departmen

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Author: El-Sayyad, Gharieb Saied × Has files: Yes ×

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  • Publication
    Open Access
    Nanobiotic formulations as promising advances for combating MRSA resistance: susceptibilities and post-antibiotic effects of clindamycin, doxycycline, and linezolid
    (Royal Society of Chemistry, 2021-12-13) Mohamed, Mennatallah A.; Nasr, Maha; Eltayeb, Wafaa N.; Elshamy, Aliaa A.; Elkhatib, Walid F.; El-Sayyad, Gharieb Saied
    Antimicrobial activity and post-antibiotic effects (PAEs) are both important parameters in determination of the dosage regimen of antimicrobial agents. In the present study, antimicrobial activity and PAEs of clindamycin, doxycycline, linezolid, and their nanobiotic formulations were evaluated against two methicillin resistant Staphylococcus aureus clinical isolates (MRSA) encoded (MRSA-S1 and MRSA-S2). Nanobiotic formulations increased the susceptibility of MRSA isolates by 4–64 folds as compared to their conventional ones. The PAE values were determined after exposure of MRSA isolates for 1 h to 10× the MICs of the tested antibiotics. The duration of PAEs were recorded after bacterial growth in Mueller Hinton broth (MHB) free from antibiotic has been restored. The PAE values for MRSA-S1 were 2.5 h for the conventional antibiotics. However, the PAEs for nanobiotics were 4 h for both clindamycin and linezolid, while 3 h for doxycycline. For MRSA-S2, linezolid and linezolid nanobiotics PAEs were 3 h. PAEs of clindamycin and clindamycin nanobiotics were 3.75 h and 4 h, respectively. Doxycycline and doxycycline nanobiotics revealed the same PAEs patterns of 3.5 h. The findings of the current study may positively influence the pharmacodynamics of the antibiotics and consequently the dosage regimen of nanobiotics as well as on their clinical outcome.
  • Publication
    Open Access
    An overview of methods for production and detection of silver nanoparticles, with emphasis on their fate and toxicological effects on human, soil, and aquatic environment
    (Walter De Gruyter, 2021-08-30) Ghobashy, Mohamed Mohamady; Abd Elkodous, Mohamed; Shabaka, Soha Hamdy; Younis, Sherif A.; Alshangiti, Dalal Mohamed; Madani, Mohamed; Al-Gahtany. Samera Ali; Noreddin, Ayman M.; Nady, Norhan; Elkhatib, Walid F.; El-Sayyad, Gharieb Saied
    Silver nanoparticles (AgNPs) have been extensively used in various industries; however, this is accompanied by several implications to humans and the environment. This review focuses on different aspects of AgNPs including the production and detection techniques, their fate, and dynamics in response to different environmental factors. In addition, this review illustrates the toxicity mechanism and the interaction of AgNPs with different matrices, such as aquatic environment, soil, crops, and humans. Reduction measures and future research are discussed.